Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance

Gabrielle C. Ngwana-Joseph, Jody E. Phelan, Emilia Manko, Jamille G. Dombrowski, Simone Silva Santos, Martha Suarez-Mutis, Gabriel Vélez-Tobón, Alberto Tobón Castaño, Ricardo Luiz Dantas Machado, Claudio R. F. Marinho, Debbie Nolder, François Nosten, Colin J. Sutherland, Susana Campino () and Taane G. Clark ()
Additional contact information
Gabrielle C. Ngwana-Joseph: London School of Hygiene and Tropical Medicine
Jody E. Phelan: London School of Hygiene and Tropical Medicine
Emilia Manko: London School of Hygiene and Tropical Medicine
Jamille G. Dombrowski: London School of Hygiene and Tropical Medicine
Simone Silva Santos: Oswaldo Cruz Foundation – Fiocruz
Martha Suarez-Mutis: Oswaldo Cruz Foundation – Fiocruz
Gabriel Vélez-Tobón: Universidad de Antioquia
Alberto Tobón Castaño: Universidad de Antioquia
Ricardo Luiz Dantas Machado: Universidade Federal Fluminense
Claudio R. F. Marinho: University of São Paulo
Debbie Nolder: London School of Hygiene and Tropical Medicine
François Nosten: University of Oxford
Colin J. Sutherland: London School of Hygiene and Tropical Medicine
Susana Campino: London School of Hygiene and Tropical Medicine
Taane G. Clark: London School of Hygiene and Tropical Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P. vivax isolates across 29 endemic countries, detailing population structure, patterns of relatedness, selection, and resistance profiling, providing insights into potential drivers of CQR. Selective sweeps in a locus proximal to pvmdr1, a putative marker for CQR, along with transcriptional regulation genes, distinguish isolates from Indonesia from those in regions where chloroquine remains highly effective. In 106 isolates from Indonesian Papua, the epicentre of CQR, we observe an increasing prevalence of novel SNPs in the candidate resistance gene pvmrp1 since the introduction of dihydroartemisinin-piperaquine. Overall, we provide novel markers for resistance surveillance, supported by evidence of regions under recent directional selection and temporal analysis in this continually evolving parasite.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-54964-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54964-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-54964-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().