Peripheral contributions to resting state brain dynamics

Sarah Bricault, Miranda Dawson, Jiyoung Lee, Mitul Desai, Miriam Schwalm, Kevin Sunho Chung, Elizabeth DeTienne, Erinn Fagan, Nan Li, Andrew Becker, Sureshkumar Muthupalani, Jan-Philipp Fränken, Dimitris A. Pinotsis and Alan Jasanoff ()
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Sarah Bricault: Massachusetts Institute of Technology
Miranda Dawson: Massachusetts Institute of Technology
Jiyoung Lee: Wellesley College
Mitul Desai: Massachusetts Institute of Technology
Miriam Schwalm: Massachusetts Institute of Technology
Kevin Sunho Chung: Massachusetts Institute of Technology
Elizabeth DeTienne: Massachusetts Institute of Technology
Erinn Fagan: Massachusetts Institute of Technology
Nan Li: Massachusetts Institute of Technology
Andrew Becker: Massachusetts Institute of Technology
Sureshkumar Muthupalani: Massachusetts Institute of Technology
Jan-Philipp Fränken: University of Edinburgh
Dimitris A. Pinotsis: University of London
Alan Jasanoff: Massachusetts Institute of Technology

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract The correlational structure of brain activity dynamics in the absence of stimuli or behavior is often taken to reveal intrinsic properties of neural function. To test the limits of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in unanesthetized, chemically immobilized male rats that emulate human neuroimaging conditions. We find that perturbation of somatosensory input channels modifies correlation strengths that relate somatosensory areas both to one another and to higher-order brain regions, despite the absence of ostensible stimuli or movements. Resting state effects are mediated by the same peripheral and thalamic structures that relay responses to overt sensory stimuli. The impact of basal peripheral input is reduced in a rat model of autism, which displays both lower somatosensory functional connectivity and insensitivity to vibrissa inactivation. These results demonstrate the influence of extrinsic influences on resting state brain phenotypes in health and disease.

Date: 2024
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DOI: 10.1038/s41467-024-55064-6

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