Femtomolar hydrogen sulfide detection via hybrid small-molecule nano-arrays

Xing Xing, Luyan Wu, Yuchen Zhang, Jiahao Pan, Yusuke Ishigaki, Huaqing Xie, Takanori Suzuki, Deju Ye, Jianhua Zhang, Weihua Zhang and Zhenda Lu ()
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Xing Xing: Nanjing University
Luyan Wu: Nanjing University
Yuchen Zhang: Nanjing University
Jiahao Pan: Nanjing University
Yusuke Ishigaki: Hokkaido University
Huaqing Xie: Shanghai Polytechnic University
Takanori Suzuki: Hokkaido University
Deju Ye: Nanjing University
Jianhua Zhang: Simpcare (GuangZhou) Biotechnology Co. Ltd.
Weihua Zhang: Nanjing University
Zhenda Lu: Nanjing University

Nature Communications, 2024, vol. 15, issue 1, 1-8

Abstract: Abstract Early disease diagnosis hinges on the sensitive detection of signaling molecules. Among these, hydrogen sulfide (H2S) has emerged as a critical player in cardiovascular and nervous system signaling. On-chip immunoassays, particularly nanoarray-based interfacial detection, offer promising avenues for ultra-sensitive analysis due to their confined reaction volumes and precise signal localization. Beyond the DNA or protein biomolecules array, this work presents a promising hybrid small molecule nano-array for H2S detection, using the power of dual molecules: a dye for fluorescence emission and a quencher with specific H2S reactivity. Upon H2S interaction, the quenched fluorescence reignites, creating an easily detectable array of bright spots. The molecule nano-array sensor shows exceptional responses to H2S over 8 magnitudes of dynamic range from 1 fM to 0.1 μM, with a remarkable detection limit of 1 fM, just using a 10 μL solution. This H2S detection method has the potential to significantly improve bioassay platforms, and the hybrid small-molecule nano-arrays we developed could be a valuable tool for advancing signaling molecule detection.

Date: 2024
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DOI: 10.1038/s41467-024-55123-y

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