In vivo imaging of glycogen in human muscle

Chongxue Bie, Yuxuan Ma, Peter C. M. Zijl, Nirbhay N. Yadav, Xi Xu, Hairong Zheng, Dong Liang, Chao Zou, José L. Areta, Lin Chen and Yang Zhou ()
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Chongxue Bie: Chinese Academy of Sciences
Yuxuan Ma: Chinese Academy of Sciences
Peter C. M. Zijl: Kennedy Krieger Institute
Nirbhay N. Yadav: Kennedy Krieger Institute
Xi Xu: Chinese Academy of Sciences
Hairong Zheng: Chinese Academy of Sciences
Dong Liang: Chinese Academy of Sciences
Chao Zou: Chinese Academy of Sciences
José L. Areta: Liverpool John Moores University
Lin Chen: Xiamen University
Yang Zhou: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Probing regional glycogen metabolism in humans non-invasively has been challenging due to a lack of sensitive approaches. Here we studied human muscle glycogen dynamics post-exercise with a spatial resolution of millimeters and temporal resolution of minutes, using relayed nuclear Overhauser effect (glycoNOE) MRI. Data at 5T showed a homogeneous distribution of glycogen in resting muscle, with an average concentration of 99 ± 13 mM. After plantar flexion exercise following fasting with recovery under fasting conditions, the calf muscle showed spatially heterogeneous glycogen depletion and repletion kinetics that correlated with the severity of this depletion. Three types of regional glycogen kinetics were observed: (i) single exponential repletion (type a); (ii) biphasic recovery of rapid repletion followed by additional depletion (type b); (iii) biphasic recovery where continued depletion is followed by an exponential recovery (type c). The study of the complex patterns of glycogen kinetics suggests that glycogen breakdown may be quantitatively important during the initial recovery.

Date: 2024
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DOI: 10.1038/s41467-024-55132-x

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