The survival of B cells is compromised in kidney disease

Doureradjou Peroumal, Chetan V. Jawale, Wonseok Choi, Hossein Rahimi, Danielle Antos, Li De-dong, Shuxia Wang, Godhev K. Manakkat Vijay, Isha Mehta, Raymond West, Muthusamy Thangaraju, Thomas D. Nolin, Jishnu Das, John F. Alcorn and Partha S. Biswas ()
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Doureradjou Peroumal: University of Pittsburgh
Chetan V. Jawale: University of Pittsburgh
Wonseok Choi: University of Pittsburgh
Hossein Rahimi: University of Pittsburgh
Danielle Antos: University of Pittsburgh
Li De-dong: University of Pittsburgh
Shuxia Wang: University of Pittsburgh
Godhev K. Manakkat Vijay: University of Pittsburgh
Isha Mehta: University of Pittsburgh
Raymond West: University of Pittsburgh
Muthusamy Thangaraju: Augusta University
Thomas D. Nolin: University of Pittsburgh
Jishnu Das: University of Pittsburgh
John F. Alcorn: University of Pittsburgh
Partha S. Biswas: University of Pittsburgh

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Antibody-mediated protection against pathogens is crucial to a healthy life. However, the recent SARS-CoV-2 pandemic has shown that pre-existing comorbid conditions including kidney disease account for compromised humoral immunity to infections. Individuals with kidney disease are not only susceptible to infections but also exhibit poor vaccine-induced antibody response. Using multiple mouse models of kidney disease, we demonstrate that renal dysfunction inhibits germinal center (GC) response against T-dependent antigens. GC B cells exhibit increased apoptosis in kidney disease. Uremic toxin hippuric acid drives loss of mitochondrial membrane potential, leading to increased apoptosis of GC B cells in a G-protein–coupled receptor 109A dependent manner. Finally, GC B cells and antibody titer are diminished in mice with kidney disease following influenza virus infection, a major cause of mortality in individuals with renal disorders. These results provide a mechanistic understanding of how renal dysfunction suppresses humoral immunity in patients with kidney disease.

Date: 2024
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DOI: 10.1038/s41467-024-55187-w

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