A critical role of action-related functional networks in Gilles de la Tourette syndrome

Juan Carlos Baldermann (), Jan Niklas Petry-Schmelzer, Thomas Schüller, Lin Mahfoud, Gregor A. Brandt, Till A. Dembek, Christina Linden, Joachim K. Krauss, Natalia Szejko, Kirsten R. Müller-Vahl, Christos Ganos, Bassam Al-Fatly, Petra Heiden, Domenico Servello, Tommaso Galbiati, Kara A. Johnson, Christopher R. Butson, Michael S. Okun, Pablo Andrade, Katharina Domschke, Gereon R. Fink, Michael D. Fox, Andreas Horn, Jens Kuhn, Veerle Visser-Vandewalle and Michael T. Barbe
Additional contact information
Juan Carlos Baldermann: Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Jan Niklas Petry-Schmelzer: Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Thomas Schüller: Faculty of Medicine and University Hospital Cologne, University of Cologne
Lin Mahfoud: Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Gregor A. Brandt: Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Till A. Dembek: Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Christina Linden: Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Joachim K. Krauss: Hannover Medical School
Natalia Szejko: University of Calgary
Kirsten R. Müller-Vahl: Socialpsychiatry and Psychotherapy, Hannover Medical School
Christos Ganos: Toronto Western Hospital
Bassam Al-Fatly: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Petra Heiden: Faculty of Medicine and University Hospital Cologne, University of Cologne
Domenico Servello: Milan
Tommaso Galbiati: Milan
Kara A. Johnson: University of Florida
Christopher R. Butson: University of Florida
Michael S. Okun: University of Florida
Pablo Andrade: Faculty of Medicine and University Hospital Cologne, University of Cologne
Katharina Domschke: Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Gereon R. Fink: Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Michael D. Fox: Harvard Medical School
Andreas Horn: Harvard Medical School
Jens Kuhn: Alexianer Köln GmbH
Veerle Visser-Vandewalle: Faculty of Medicine and University Hospital Cologne, University of Cologne
Michael T. Barbe: Faculty of Medicine and University Hospital Cologne, University of Cologne

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants. We find that greater tic reduction is linked to higher connectivity of DBS sites (N = 37) with action-related functional resting-state networks, i.e., the cingulo-opercular (r = 0.62; p

Date: 2024
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DOI: 10.1038/s41467-024-55242-6

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