Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma

Fang Wang, Jiawei Dong, Yuyun Xu, Jiaqi Jin, Yan Xu, Xiuwei Yan, Zhihui Liu, Hongtao Zhao, Jiheng Zhang, Nan Wang, Xueyan Hu, Xin Gao, Lei Xu, Chengyun Yang, Shuai Ma, Jianyang Du, Ying Hu (), Hang Ji () and Shaoshan Hu ()
Additional contact information
Fang Wang: Hangzhou Medical College
Jiawei Dong: Hangzhou Medical College
Yuyun Xu: Hangzhou Medical College
Jiaqi Jin: Hangzhou Medical College
Yan Xu: Hangzhou Medical College
Xiuwei Yan: Hangzhou Medical College
Zhihui Liu: Hangzhou Medical College
Hongtao Zhao: Hangzhou Medical College
Jiheng Zhang: Hangzhou Medical College
Nan Wang: Hangzhou Medical College
Xueyan Hu: Hangzhou Medical College
Xin Gao: Hangzhou Medical College
Lei Xu: Hangzhou Medical College
Chengyun Yang: Hangzhou Medical College
Shuai Ma: Hangzhou Medical College
Jianyang Du: Hangzhou Medical College
Ying Hu: Hangzhou Medical College
Hang Ji: Hangzhou Medical College
Shaoshan Hu: Hangzhou Medical College

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging. We assess the microenvironment and the characteristics of infiltrating immune/tumor cells using various techniques. Our data indicate there are one or more regions with higher cerebral blood flow in PBZ, which we collectively name the “higher cerebral blood flow interface” (HBI). The HBI exhibited more neovascularization than the “lower cerebral blood flow interfaces” (LBI). The HBI tend to have increased infiltration of macrophages and T lymphocytes infiltration compared with that in LBI. There are more tumor cells in the HBI than in LBI, with substantial differences in the gene expression profiles of these tumor cells. HBI may be the key area of PBZ-targeting therapy after surgical resection.

Date: 2024
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DOI: 10.1038/s41467-024-55243-5

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