Broadscale dampening of uncertainty adjustment in the aging brain

Julian Q. Kosciessa (), Ulrich Mayr, Ulman Lindenberger and Douglas D. Garrett ()
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Julian Q. Kosciessa: Max Planck UCL Centre for Computational Psychiatry and Ageing Research
Ulrich Mayr: University of Oregon
Ulman Lindenberger: Max Planck UCL Centre for Computational Psychiatry and Ageing Research
Douglas D. Garrett: Max Planck UCL Centre for Computational Psychiatry and Ageing Research

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract The ability to prioritize among input features according to relevance enables adaptive behaviors across the human lifespan. However, relevance often remains ambiguous, and such uncertainty increases demands for dynamic control. While both cognitive stability and flexibility decline during healthy ageing, it is unknown whether aging alters how uncertainty impacts perception and decision-making, and if so, via which neural mechanisms. Here, we assess uncertainty adjustment across the adult lifespan (N = 100; cross-sectional) via behavioral modeling and a theoretically informed set of EEG-, fMRI-, and pupil-based signatures. On the group level, older adults show a broad dampening of uncertainty adjustment relative to younger adults. At the individual level, older individuals whose modulation more closely resembled that of younger adults also exhibit better maintenance of cognitive control. Our results highlight neural mechanisms whose maintenance plausibly enables flexible task-set, perception, and decision computations across the adult lifespan.

Date: 2024
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DOI: 10.1038/s41467-024-55416-2

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