A reagent to access methyl sulfones

Yaroslav Poplavskyi, Vasyl Ripenko, Sergei Bova, Angelina Biitseva, Yurii V. Dmitriv, Andrei A. Tolmachev, Iryna V. Sadkova, Iryna Pishel, Oleksii Grygorov, Vo Quang Huy Phan, H. V. Rasika Dias () and Pavel K. Mykhailiuk ()
Additional contact information
Yaroslav Poplavskyi: Enamine Ltd
Vasyl Ripenko: Enamine Ltd
Sergei Bova: Enamine Ltd
Angelina Biitseva: Enamine Ltd
Yurii V. Dmitriv: Enamine Ltd
Andrei A. Tolmachev: Enamine Ltd
Iryna V. Sadkova: Enamine Ltd
Iryna Pishel: Bienta
Oleksii Grygorov: Bienta
Vo Quang Huy Phan: The University of Texas at Arlington
H. V. Rasika Dias: The University of Texas at Arlington
Pavel K. Mykhailiuk: Enamine Ltd

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.

Date: 2025
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DOI: 10.1038/s41467-024-55027-x

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