Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function

Erkka Valo, Anne Richmond, Stefan Mutter, Emma H. Dahlström, Archie Campbell, David J. Porteous, James F. Wilson, Per-Henrik Groop, Caroline Hayward () and Niina Sandholm ()
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Erkka Valo: Folkhälsan Research Center
Anne Richmond: Western General Hospital
Stefan Mutter: Folkhälsan Research Center
Emma H. Dahlström: Folkhälsan Research Center
Archie Campbell: Western General Hospital
David J. Porteous: Western General Hospital
James F. Wilson: Western General Hospital
Per-Henrik Groop: Folkhälsan Research Center
Caroline Hayward: Western General Hospital
Niina Sandholm: Folkhälsan Research Center

Nature Communications, 2025, vol. 16, issue 1, 1-16

Abstract: Abstract Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary metabolite profiling, as widely applied for blood biomarker studies. Here we report a genome-wide association study meta-analysed for 3 European cohorts comprising 8,011 individuals, covering both people with type 1 diabetes and general population settings. We identify 54 associations (p

Date: 2025
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DOI: 10.1038/s41467-024-55182-1

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