Cooperative integration of spatially resolved multi-omics data with COSMOS

Yuansheng Zhou, Xue Xiao, Lei Dong, Chen Tang, Guanghua Xiao () and Lin Xu ()
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Yuansheng Zhou: University of Texas Southwestern Medical Center
Xue Xiao: University of Texas Southwestern Medical Center
Lei Dong: University of Texas Southwestern Medical Center
Chen Tang: University of Texas Southwestern Medical Center
Guanghua Xiao: University of Texas Southwestern Medical Center
Lin Xu: University of Texas Southwestern Medical Center

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract Recent advancements in biological technologies have enabled the measurement of spatially resolved multi-omics data, yet computational algorithms for this purpose are scarce. Existing tools target either single omics or lack spatial integration. We generate a graph neural network algorithm named COSMOS to address this gap and demonstrated the superior performance of COSMOS in domain segmentation, visualization, and spatiotemporal map for spatially resolved multi-omics data integration tasks.

Date: 2025
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DOI: 10.1038/s41467-024-55204-y

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