Viral RNA polymerase as a SUMOylation decoy inhibits RNA quality control to promote potyvirus infection

Linhao Ge, Mingxuan Jia, Hongying Shan, Weifang Gao, Lu Jiang, Hongguang Cui, Xiaofei Cheng, Marilyne Uzest, Xueping Zhou, Aiming Wang and Fangfang Li ()
Additional contact information
Linhao Ge: Chinese Academy of Agricultural Sciences
Mingxuan Jia: Chinese Academy of Agricultural Sciences
Hongying Shan: Chinese Academy of Agricultural Sciences
Weifang Gao: Chinese Academy of Agricultural Sciences
Lu Jiang: Chinese Academy of Agricultural Sciences
Hongguang Cui: Hainan University
Xiaofei Cheng: Northeast Agricultural University
Marilyne Uzest: Univ Montpellier, INRAE, CIRAD, Institut Agro, IRD
Xueping Zhou: Chinese Academy of Agricultural Sciences
Aiming Wang: Agriculture and Agri-Food Canada
Fangfang Li: Chinese Academy of Agricultural Sciences

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract Potyvirids are the largest group of plant RNA viruses. Pelota, a core component of RNA quality controls (RQC), promotes the degradation of potyvirids’ genomic RNA by recognizing a specific G1-2A6-7 motif. Here we demonstrate that the viral RNA-dependent RNA polymerase, NIb, acts as a SUMOylation decoy to effectively reduce Pelota SUMOylation by competing with SCE1 to inhibit Pelota-mediated RQC. TuMV NIb is comprised of two functional SUMO interacting motif (SIM): SIM2 and SIM3. The former is identified as the key site for NIb’s SUMOylation by SUMO3, whereas the latter is responsible for the interaction with SCE1. These two SIMs are conserved among the majority of potyvirids-encoded NIbs. Thus, virus protein-mediated SUMOylation decoy strategy to suppress host defense may be a common feature in plant virus pathosystems. These findings highlight a dynamic interplay between plant defense mechanism and viral counter-strategy by orchestrating the post-translational modifications of virus and host defense components.

Date: 2025
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-55288-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55288-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-55288-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().