One-year mortality and re-admission rate by disease etiology in National Heart Failure Registry of India

Sivadasanpillai Harikrishnan, Ajay Bahl, Ambuj Roy, Animesh Mishra, Jayesh Prajapati, Manjunath Cn, Rishi Sethi, Santanu Guha, Santhosh Satheesh, Dhaliwal Rs, Meenakshi Sharma, Sanjay Ganapathy and Panniyammakal Jeemon ()
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Sivadasanpillai Harikrishnan: Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)
Ajay Bahl: Postgraduate Institute of Medical Education and Research (PGIMER)
Ambuj Roy: All India Institute of Medical Sciences (AIIMS)
Animesh Mishra: North-Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS)
Jayesh Prajapati: UN Mehta Institute of Cardiology and Research Centre (UNMICRC)
Manjunath Cn: Sri Jayadeva Institute of Cardiovascular Sciences and Research (SJICR)
Rishi Sethi: King George’s Medical University (KGMU)
Santanu Guha: Medical College Hospital (MCH)
Santhosh Satheesh: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
Dhaliwal Rs: Indian Council of Medical Research (ICMR)
Meenakshi Sharma: Indian Council of Medical Research (ICMR)
Sanjay Ganapathy: Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)
Panniyammakal Jeemon: Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)

Nature Communications, 2025, vol. 16, issue 1, 1-7

Abstract: Abstract Survival outcomes of patients with heart failure (HF) based on their disease etiology are not well described. Here, we provide one-year mortality outcomes of 10850 patients with HF (mean age = 59.9 years, 31% women) in India. Ischemic heart disease (71.9%), dilated cardiomyopathy (17.3), rheumatic heart disease (5.4), non-rheumatic valvular heart disease (1.9), hypertrophic cardiomyopathy (0.8), congenital heart disease (0.7), peri-partum cardiomyopathy (0.5), restrictive cardiomyopathy (0.4), and infective endocarditis (0.1) were the main disease etiologies. Mortality rate per 100-person years of follow-up varied from 13.8 (95% CI: 6.2–30.7) in peri-partum cardiomyopathy to 92.9 (46.5–185.9) in infective endocarditis. Compared to ischemic heart disease, the mortality was two to five times higher in rheumatic heart disease (HR = 2.0; 95% CI: 1.6–2.4), congenital heart disease (2.9; 1.9–4.2), and infective endocarditis (4.8; 2.4–9.8). The wide variations in mortality rate in HF patients may bring possible clinical applicability of risk stratification.

Date: 2025
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DOI: 10.1038/s41467-024-55362-z

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