Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans

Leonhard Waschke, Fabian Kamp, Evi Elzen, Suresh Krishna, Ulman Lindenberger, Ueli Rutishauser and Douglas D. Garrett ()
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Leonhard Waschke: Max Planck Institute for Human Development
Fabian Kamp: Max Planck Institute for Human Development
Evi Elzen: Tilburg University
Suresh Krishna: McGill University
Ulman Lindenberger: Max Planck Institute for Human Development
Ueli Rutishauser: Cedars-Sinai Medical Center
Douglas D. Garrett: Max Planck Institute for Human Development

Nature Communications, 2025, vol. 16, issue 1, 1-9

Abstract: Abstract During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.

Date: 2025
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DOI: 10.1038/s41467-024-55406-4

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