A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging

Cheng Yao, Ruwei Wei, Xiao Luo, Jie Zhou, Xiaodong Zhang, Xicun Lu, Yan Dong, Ruofan Chu, Yuxin Sun, Yu Wang, Wencheng Xia, Dahui Qu, Cong Liu, Jun Ren, Guangbo Ge, Jinquan Chen, Xuhong Qian and Youjun Yang ()
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Cheng Yao: East China University of Science and Technology
Ruwei Wei: East China University of Science and Technology
Xiao Luo: East China Normal University
Jie Zhou: East China Normal University
Xiaodong Zhang: East China University of Science and Technology
Xicun Lu: East China University of Science and Technology
Yan Dong: East China University of Science and Technology
Ruofan Chu: East China University of Science and Technology
Yuxin Sun: East China University of Science and Technology
Yu Wang: East China Normal University
Wencheng Xia: Chinese Academy of Sciences
Dahui Qu: East China University of Science and Technology
Cong Liu: Chinese Academy of Sciences
Jun Ren: Hubei University
Guangbo Ge: Shanghai University of Traditional Chinese Medicine
Jinquan Chen: East China Normal University
Xuhong Qian: East China University of Science and Technology
Youjun Yang: East China University of Science and Technology

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR spectral activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of dye aggregation remains challenging. We propose a crystal-aided aggregate synthesis (CAASH) approach to introduce a layer of rationality for the development of J-aggregate and the successful development of a water-soluble SWIR JV-aggregate with a bisbenzannulated silicon rhodamine scaffold (ESi5). The resulting SWIR-aggregates exhibit excellent stabilities toward organic solvents, pH, sonication, photobleaching, thiols, and endogenous oxidative species. Notably, the aggregates have a high structure-dependent melting temperature of ca. 330-335 K. In fact, the heating/annealing process can be exploited to reduce aggregation disorder. The aggregates are biocompatible and have broad potential in in vivo fluorescence and photoacoustic imaging and more.

Date: 2025
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DOI: 10.1038/s41467-024-55445-x

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