Molecular Engineering of Direct Activated NIR-II Chemiluminescence Platform for In Vivo Chemiluminescence-fluorescence Duplex Imaging

Zhongxiang Chen, Qian Li, Ying Wu, Jianyong Liu, Luntao Liu, Lichao Su, Rongrong Wu and Jibin Song ()
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Zhongxiang Chen: Beijing University of Chemical Technology
Qian Li: Fuzhou University
Ying Wu: Beijing University of Chemical Technology
Jianyong Liu: Fuzhou University
Luntao Liu: Fuzhou University
Lichao Su: Fuzhou University
Rongrong Wu: Fuzhou University
Jibin Song: Beijing University of Chemical Technology

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract Chemiluminescence (CL) is a self-illuminating phenomenon fueled by chemical energy instead of extra excited light, which features superiority in sensitivity, signal-to-background ratios, and imaging depth. Strategies to synthesize a CL emission unimolecular skeleton in the second near-infrared window (NIR-II) and a unimolecular probe with direct duplex NIR-II [CL/fluorescence (FL)] emission are lacking. Here, we employ modular synthesis routes to construct a series of directly activated NIR-II CL emission unimolecular probes with a maximum emission wavelength of up to 1060 nm, and use them for real-time and continuous detection of the superoxide anion generated in acetaminophen induced liver injury in a female mice model under both NIR-II CL and NIR-II FL imaging channels. Thus, this study establishes a directly activatable NIR-II CL emission unimolecular skeleton, validating the scalability of this duplex NIR-II CL/FL imaging platform in bioactive molecule detection and disease diagnosis.

Date: 2025
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DOI: 10.1038/s41467-024-55503-4

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