Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes

Xiao-Yan Zhu, Wenyu Gao, Jian-Lin Xu, Zi-Lu Wang, Jin-Bo Zhao () and Yun-He Xu ()
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Xiao-Yan Zhu: University of Science and Technology of China
Wenyu Gao: Changchun University of Technology
Jian-Lin Xu: University of Science and Technology of China
Zi-Lu Wang: University of Science and Technology of China
Jin-Bo Zhao: Changchun University of Technology
Yun-He Xu: University of Science and Technology of China

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract This study presents a copper-catalyzed, substrate-controlled regio- and enantioselective intermolecular hydrosilylation method capable of accommodating a broad scope of alkenes and prochiral silanes. The approach offers an efficient and versatile pathway to generate enantioenriched linear and branched alkyl-substituted Si-stereogenic silanes. Key features of this reaction include mild reaction conditions, simple catalytic systems, compatibility with diverse substrates, high yields and enantioselectivities.

Date: 2025
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DOI: 10.1038/s41467-024-55592-1

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