mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae

Brady Dolan, Tomás Correa Gaviria, Yuemei Dong, Peter Cresswell, George Dimopoulos, Yu-Min Chuang () and Erol Fikrig ()
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Brady Dolan: Yale University School of Medicine
Tomás Correa Gaviria: Yale University School of Medicine
Yuemei Dong: Johns Hopkins University
Peter Cresswell: Yale University School of Medicine
George Dimopoulos: Johns Hopkins University
Yu-Min Chuang: Yale University School of Medicine
Erol Fikrig: Yale University School of Medicine

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract Plasmodium, the causative agents of malaria, are obtained by mosquitoes from an infected human. Following Plasmodium acquisition by Anopheles gambiae, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT) plays a critical role in its subsequent sporogony in the mosquito. A critical location for this development is the midgut, a tissue we show expresses mosGILT. Using membrane-feeding and murine infection models, we demonstrate that antibodies against mosGILT reduce the number of P. falciparum and P. berghei oocysts in the midgut and the infection prevalence of both species in the mosquito. mosGILT antibodies act in the mosquito midgut, specifically impacting the Plasmodium oocyst stage. Targeting mosGILT can therefore interfere with the Plasmodium life cycle in the mosquito and potentially serve as a transmission-blocking vaccine.

Date: 2025
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DOI: 10.1038/s41467-025-55902-1

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