Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning

Yue Pang (pangyue01@163.com), Yating Qin, Zeyu Du, Qun Liu, Jin Zhang, Kai Han, Jiali Lu, Zengbao Yuan, Jun Li, Shanshan Pan, Xinrui Dong, Mengyang Xu, Dantong Wang, Shuo Li, Zhen Li, Yadong Chen, Zhisheng Zhao, Zhe Zhang, Shunqin Chuan, Yue Song, Mingjie Sun, Xiaodong Jia, Zhangyong Xia, Liping Zhan, Zhen Yue, Wei Cui, Jun Wang, Ying Gu, Ming Ni, Huanming Yang, Xun Xu, Xin Liu (liuxin@genomics.cn), Qingwei Li (lmianyizu@163.com) and Guangyi Fan (fanguangyi@genomics.cn)
Additional contact information
Yue Pang: Liaoning Normal University
Yating Qin: BGI Research
Zeyu Du: Liaoning Normal University
Qun Liu: BGI Research
Jin Zhang: Liaoning Normal University
Kai Han: BGI Research
Jiali Lu: Liaoning Normal University
Zengbao Yuan: BGI Research
Jun Li: Liaoning Normal University
Shanshan Pan: BGI Research
Xinrui Dong: Liaoning Normal University
Mengyang Xu: BGI Research
Dantong Wang: BGI Research
Shuo Li: Chinese Academy of Fishery Sciences
Zhen Li: BGI Research
Yadong Chen: BGI Research
Zhisheng Zhao: Liaoning Normal University
Zhe Zhang: MGI Tech
Shunqin Chuan: Liaoning Normal University
Yue Song: BGI Research
Mingjie Sun: Liaoning Normal University
Xiaodong Jia: Liaocheng People’s Hospital
Zhangyong Xia: The Second People’s Hospital of Liaocheng
Liping Zhan: BGI Research
Zhen Yue: BGI Research
Wei Cui: BGI Research
Jun Wang: BGI Research
Ying Gu: BGI Research
Ming Ni: MGI Tech
Huanming Yang: BGI Research
Xun Xu: BGI Research
Xin Liu: BGI Research
Qingwei Li: Liaoning Normal University
Guangyi Fan: BGI Research

Nature Communications, 2025, vol. 16, issue 1, 1-14

Abstract: Abstract Lampreys are early jawless vertebrates that are the key to understanding the evolution of vertebrates. However, the lack of cytomic studies on multiple lamprey organs has hindered progress in this field. Therefore, the present study constructed a comprehensive cell atlas comprising 604,460 cells/nuclei and 70 cell types from 14 lamprey tissue samples. Comparison of cellular evolution across species revealed that most lamprey cell types are homologous to those in jawed vertebrates. We discovered acinar- and islet-like cell populations despite the lack of parenchymal organs in lampreys, providing evidence of pancreatic function in vertebrates. Furthermore, we investigated the heterogeneity of lamprey immune cell populations. Natterin was highly expressed in granulocytes, and NATTERIN was localized to the lipid droplets. Moreover, we developed a transgenic mouse model expressing Natterin to elucidate the role of NATTERIN in lipid metabolism, whereas the browning of white adipose tissue was induced. These findings elucidate vertebrate cellular evolution and advance our understanding of adipose tissue plasticity and metabolic regulation in lampreys.

Date: 2025
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DOI: 10.1038/s41467-025-56153-w

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