Enantioselective reductive cross-couplings to forge C(sp2)–C(sp3) bonds by merging electrochemistry with nickel catalysis

Yun-Zhao Wang, Bing Sun, Jian-Feng Guo, Xiao-Yu Zhu, Yu-Cheng Gu, Ya-Ping Han, Cong Ma and Tian-Sheng Mei ()
Additional contact information
Yun-Zhao Wang: Chinese Academy of Sciences
Bing Sun: Chinese Academy of Sciences
Jian-Feng Guo: Chinese Academy of Sciences
Xiao-Yu Zhu: Chinese Academy of Sciences
Yu-Cheng Gu: Jealott’s Hill International Research Centre
Ya-Ping Han: Hebei University of Technology
Cong Ma: Chinese Academy of Sciences
Tian-Sheng Mei: Chinese Academy of Sciences

Nature Communications, 2025, vol. 16, issue 1, 1-8

Abstract: Abstract Motivated by the inherent benefits of synergistically combining electrochemical methodologies with nickel catalysis, we present here a Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yielding chiral 1,1-diaryl compounds with good to excellent enantioselectivity. This catalytic reaction can not only be applied to aryl chlorides/bromides, which are challenging to access by other means, but also to benzyl chlorides containing silicon groups. Additionally, the absence of a sacrificial anode lays a foundation for scalability. The combination of cyclic voltammetry analysis with electrode potential studies suggests that NiI species activate aryl halides via oxidative addition and alkyl chlorides via single electron transfer.

Date: 2025
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-56377-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56377-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-56377-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().