Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process

Kevin Tatoueix, Marco Lepron, Cédric Barboux, Marie-Christine Scherrmann, Grégory Pieters () and Sophie Feuillastre ()
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Kevin Tatoueix: DMTS
Marco Lepron: DMTS
Cédric Barboux: DMTS
Marie-Christine Scherrmann: Université Paris-Saclay, CNRS, ICMMO
Grégory Pieters: DMTS
Sophie Feuillastre: DMTS

Nature Communications, 2025, vol. 16, issue 1, 1-9

Abstract: Abstract Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and smart materials. While hydrogen deuterium exchange (HDE) methods hold promise as relevant tools for the late-stage and one-step preparation of deuterium-labelled compounds, they often fall short in achieving sufficient isotopic purity combined either with a site-selectivity or with a full deuteration process, highlighting the need for further development and optimisation. This report pinpoints an approach to unlock the potential of HDE using the concept of iterative runs in continuous-flow technology (recirculation process). This closed-loop process grants access now to deuterated compounds with high isotopic purities, labelled at a precise site or perdeuterated on demand, in a fast, productive, and environmentally friendly way.

Date: 2025
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DOI: 10.1038/s41467-025-56600-8

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