Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis

Wenpin Qin, Zhangyu Ma, Guo Bai, Wen Qin, Ling Li, Dongxiao Hao, Yuzhu Wang, Jianfei Yan, Xiaoxiao Han, Wen Niu (), Lina Niu () and Kai Jiao ()
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Wenpin Qin: The Fourth Military Medical University
Zhangyu Ma: The Fourth Military Medical University
Guo Bai: Shanghai Jiao Tong University School of Medicine
Wen Qin: The Fourth Military Medical University
Ling Li: The Fourth Military Medical University
Dongxiao Hao: The Fourth Military Medical University
Yuzhu Wang: The Fourth Military Medical University
Jianfei Yan: The Fourth Military Medical University
Xiaoxiao Han: The Fourth Military Medical University
Wen Niu: The Fourth Military Medical University
Lina Niu: The Fourth Military Medical University
Kai Jiao: The Fourth Military Medical University

Nature Communications, 2025, vol. 16, issue 1, 1-17

Abstract: Abstract Treating osteoarthritis (OA) associated pain is a challenge with the potential to significantly improve patients lives. Here, we report on a hydrogel for extracellular RNA scavenging and releasing bevacizumab to block neurovascularization at the osteochondral interface, thereby mitigating OA pain and disease progression. The hydrogel is formed by cross-linking aldehyde-phenylboronic acid-modified sodium alginate/polyethyleneimine-grafted protocatechuic acid (OSAP/PPCA) and bevacizumab sustained-release nanoparticles (BGN@Be), termed OSPPB. The dynamic Schiff base bonds and boronic ester bonds allow for injectability, self-healing, and pH/reactive oxygen species dual responsiveness. The OSPPB hydrogel can significantly inhibit angiogenesis and neurogenesis in vitro. In an in vivo OA model, intraarticular injection of OSPPB accelerates the healing process of condyles and alleviates chronic pain by inhibiting neurovascularization at the osteochondral interface. The injectable hydrogel represents a promising technique to treat OA and OA associated pain.

Date: 2025
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DOI: 10.1038/s41467-025-56727-8

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