Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure

Qing-Wen Ren, Tiew-Hwa Katherine Teng, Wouter Ouwerkerk, Yi-Kei Tse, Christopher Tze Wei Tsang, Mei-Zhen Wu, Hung-Fat Tse, Adriaan A. Voors, Jasper Tromp, Carolyn S. P. Lam and Kai-Hang Yiu ()
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Qing-Wen Ren: The University of Hong Kong Shen Zhen Hospital
Tiew-Hwa Katherine Teng: National Heart Centre
Wouter Ouwerkerk: National Heart Centre
Yi-Kei Tse: Queen Mary Hospital
Christopher Tze Wei Tsang: Queen Mary Hospital
Mei-Zhen Wu: The University of Hong Kong Shen Zhen Hospital
Hung-Fat Tse: The University of Hong Kong Shen Zhen Hospital
Adriaan A. Voors: Department of Cardiology
Jasper Tromp: National Heart Centre
Carolyn S. P. Lam: National Heart Centre
Kai-Hang Yiu: The University of Hong Kong Shen Zhen Hospital

Nature Communications, 2025, vol. 16, issue 1, 1-11

Abstract: Abstract Remnant cholesterol, identified by triglyceride-rich lipoprotein, is a significant causal risk factor for ischemic heart diseases. The association of triglyceride levels with all-cause and cause-specific outcomes in heart failure (HF) remains unexplored. Using a previously validated territory-wide clinical information registry, all eligible patients diagnosed with HF (N = 127124) from 2000 to 2020 were included. In this population-based cohort (mean age: 71.4 ± 12.2 years, 51.8% male), the association between triglyceride levels and risk of all-cause mortality and cardiovascular disease was a U-shapedḍ curve. High triglyceride levels (≥3.0 mmol/L) were associated with atherosclerotic cardiovascular disease admission or death; conversely, lower triglyceride levels (

Date: 2025
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DOI: 10.1038/s41467-025-56790-1

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