A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

Friederike Grandke, Tobias Fehlmann, Fabian Kern, David M. Gate, Tobias William Wolff, Olivia Leventhal, Divya Channappa, Pascal Hirsch, Edward N. Wilson, Eckart Meese, Chuanyu Liu, Quan Shi, Matthias Flotho, Yongping Li, Cynthia Chen, Yeya Yu, Jiangshan Xu, Michael Junkin, Zhifeng Wang, Tao Wu, Longqi Liu, Yong Hou, Katrin I. Andreasson, Jenny S. Gansen, Elvira Mass, Kathleen Poston, Tony Wyss-Coray () and Andreas Keller ()
Additional contact information
Friederike Grandke: Saarland University
Tobias Fehlmann: Saarland University
Fabian Kern: Saarland University
David M. Gate: Stanford University
Tobias William Wolff: Saarland University
Olivia Leventhal: Stanford University
Divya Channappa: Stanford University
Pascal Hirsch: Saarland University
Edward N. Wilson: Stanford University
Eckart Meese: Saarland University
Chuanyu Liu: MGI Group
Quan Shi: MGI Group
Matthias Flotho: Saarland University
Yongping Li: Saarland University
Cynthia Chen: MGI Group
Yeya Yu: MGI Group
Jiangshan Xu: MGI Group
Michael Junkin: MGI Group
Zhifeng Wang: MGI Group
Tao Wu: MGI Group
Longqi Liu: MGI Group
Yong Hou: MGI Group
Katrin I. Andreasson: Stanford University
Jenny S. Gansen: Saarland University
Elvira Mass: University of Bonn
Kathleen Poston: Stanford University
Tony Wyss-Coray: Stanford University
Andreas Keller: Saarland University

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference and chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our understanding of observed peripheral changes in neurodegeneration. Here, we employ single-cell gene expression profiling of over 909k peripheral blood mononuclear cells (PBMCs) from 121 healthy individuals, 48 patients with mild cognitive impairment (MCI), 46 with Parkinson’s disease (PD), 27 with Alzheimer’s disease (AD), and 15 with both PD and MCI. The dataset is interactively accessible through a freely available website ( https://www.ccb.uni-saarland.de/adrcsc ). In this work, we identify disease-associated changes in blood cell type composition and the gene expression in a sex-specific manner, offering insights into peripheral and solid tissue signatures in AD and PD.

Date: 2025
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-56833-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56833-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-56833-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().