TaTCP6 is required for efficient and balanced utilization of nitrate and phosphorus in wheat

Bin Liu, Weiya Xu, Yanxiao Niu, Qiuyuan Li, Beilu Cao, Jingyi Qi, Yidi Zhao, Yilan Zhou, Long Song, Dongkai Cui, Zhenshan Liu, Mingming Xin, Yingyin Yao, Mingshan You, Zhongfu Ni, Qixin Sun and Jiewen Xing ()
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Bin Liu: China Agricultural University
Weiya Xu: China Agricultural University
Yanxiao Niu: China Agricultural University
Qiuyuan Li: China Agricultural University
Beilu Cao: China Agricultural University
Jingyi Qi: China Agricultural University
Yidi Zhao: China Agricultural University
Yilan Zhou: China Agricultural University
Long Song: China Agricultural University
Dongkai Cui: Northwest A&F University
Zhenshan Liu: Northwest A&F University
Mingming Xin: China Agricultural University
Yingyin Yao: China Agricultural University
Mingshan You: China Agricultural University
Zhongfu Ni: China Agricultural University
Qixin Sun: China Agricultural University
Jiewen Xing: China Agricultural University

Nature Communications, 2025, vol. 16, issue 1, 1-19

Abstract: Abstract High crop yields require adequate nutrients, particularly nitrate (N) and phosphorus (P). Identifying regulators for efficient N-P utilization is critical in wheat. To explore N-P interactions, we analyze root transcriptomes under varying N-P supplies and identify TaTCP6 as a potential regulator. Nitrate-stimulated TaTCP6 directly triggers the expression of genes related to nitrogen utilization. TaTCP6 competes with TaSPX1/4 for the release of TaPHR2, and also interacts with TaPHR2 to enhance the transactivation capacity of downstream genes. Thus, through the dual roles of TaTCP6, the TCP6-SPX-PHR2 module activates the expression of phosphorus starvation response (PSR) genes. Inhibiting TaTCP6 reduces N and P absorption, negatively impacting yield, while overexpressing TaTCP6 increases grain yield. Notably, overexpression of TaSPX1 suppresses nitrogen utilization genes, especially under low phosphorus conditions. In conclusion, our findings highlight the role of TaTCP6 in coordinating N and P utilization and propose a strategy to reduce fertilizer inputs for sustainable agriculture.

Date: 2025
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DOI: 10.1038/s41467-025-57008-0

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