Bioactive nanomotor enabling efficient intestinal barrier penetration for colorectal cancer therapy

Zhi-Hao Wang, Xuejiao Zeng, Wanting Huang, Yanbo Yang, Shuhao Zhang, Mingzhu Yang, Hua Liu, Fengqin Zhao, Airong Li, Zhenzhong Zhang (), Junjie Liu () and Jinjin Shi ()
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Zhi-Hao Wang: Zhengzhou University
Xuejiao Zeng: Zhengzhou University
Wanting Huang: Zhengzhou University
Yanbo Yang: Zhengzhou University
Shuhao Zhang: Zhengzhou University
Mingzhu Yang: Zhengzhou University
Hua Liu: Zhengzhou University
Fengqin Zhao: Zhengzhou University
Airong Li: Zhengzhou University
Zhenzhong Zhang: Zhengzhou University
Junjie Liu: Zhengzhou University
Jinjin Shi: Zhengzhou University

Nature Communications, 2025, vol. 16, issue 1, 1-19

Abstract: Abstract Oral drug delivery systems had natural potential for colorectal cancer drug therapy. While the drug delivery efficiency is severely hindered by the complex intestinal barriers, especially mucus and epithelium barriers, resulting in unsatisfactory therapeutic effects and limited clinical translation. In this work, a bioactive self-thermophoretic and gas dual-driven nanomotor is developed for colorectal cancer therapy through efficient intestinal mucus and epithelial barrier penetration. The nanomotor shows intestinal mucus barrier penetration and the paracellular pathway reversibly opening properties of intestinal epithelium barrier, increasing the delivery efficiency of cisplatin by 3.5 folds. Owing to the targeted delivery of cisplatin and the reduced side effects on normal intestinal tissues, the therapeutic efficiency of the nanomotor for colorectal cancer in vivo is as high as 98.6%. With autonomous and reversible intestinal barriers penetration property, the nanoplatform may innovate the current oral drug delivery.

Date: 2025
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DOI: 10.1038/s41467-025-57045-9

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