Striatal arbitration between choice strategies guides few-shot adaptation

Minsu Abel Yang, Min Whan Jung and Sang Wan Lee ()
Additional contact information
Minsu Abel Yang: Korea Advanced Institute of Science and Technology (KAIST)
Min Whan Jung: Institute for Basic Science
Sang Wan Lee: Korea Advanced Institute of Science and Technology (KAIST)

Nature Communications, 2025, vol. 16, issue 1, 1-26

Abstract: Abstract Animals often exhibit rapid action changes in context-switching environments. This study hypothesized that, compared to the expected outcome, an unexpected outcome leads to distinctly different action-selection strategies to guide rapid adaptation. We designed behavioral measures differentiating between trial-by-trial dynamics after expected and unexpected events. In various reversal learning data with different rodent species and task complexities, conventional learning models failed to replicate the choice behavior following an unexpected outcome. This discrepancy was resolved by the proposed model with two different decision variables contingent on outcome expectation: the support-stay and conflict-shift bias. Electrophysiological data analyses revealed that striatal neurons encode our model’s key variables. Furthermore, the inactivation of striatal direct and indirect pathways neutralizes the effect of past expected and unexpected outcomes, respectively, on the action-selection strategy following an unexpected outcome. Our study suggests unique roles of the striatum in arbitrating between different action selection strategies for few-shot adaptation.

Date: 2025
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-57049-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57049-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-57049-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().