Calcium levels in ASER neurons determine behavioral valence by engaging distinct neuronal circuits in C. elegans

Weikang Xue, Yuanhua Chen (), Ziyi Lei, Yuanxia Wang, Jiaze Liu, Xin Wen, Fang Xu, Pu Chen, Zhengxing Wu, Youngnam N. Jin () and Yanxun V. Yu ()
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Weikang Xue: Wuhan University
Yuanhua Chen: Wuhan University
Ziyi Lei: Wuhan University
Yuanxia Wang: Wuhan University
Jiaze Liu: Wuhan University
Xin Wen: Henan Agricultural University
Fang Xu: Wuhan University
Pu Chen: Wuhan University
Zhengxing Wu: Huazhong University of Science and Technology
Youngnam N. Jin: Wuhan University
Yanxun V. Yu: Wuhan University

Nature Communications, 2025, vol. 16, issue 1, 1-17

Abstract: Abstract The valence of stimuli is shaped by various factors, including environmental cues, internal states, genetic variability, and past experience. However, the mechanisms behind this flexibility remain elusive. In the nematode C. elegans, we found that ethanol, an olfactory stimulus, can elicit opposite chemotaxis responses – attraction vs. aversion – depending on NaCl concentration, demonstrating the role of environmental factors in altering valence. Remarkably, a single chemosensory neuron, ASER, orchestrate this bidirectional ethanol chemotaxis by integrating information from both stimuli – ethanol and NaCl – into its neuronal activity dynamics. Specifically, different calcium dynamics in the ASER neuron differentially activate the signaling molecule CMK-1, thereby engaging different downstream interneurons and leading to opposite chemotaxis directions. Consistently, optogenetic manipulations of the ASER neuron reverse the chemotaxis directions, by altering its calcium dynamics. Our findings reveal a mechanism by which a single neuron integrates multisensory inputs to determine context-dependent behavioral valence, contributing to our current understanding of valence encoding.

Date: 2025
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DOI: 10.1038/s41467-025-57051-x

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