Keratinocyte-driven dermal collagen formation in the axolotl skin

Ayaka Ohashi, Hirotaka Sakamoto, Junpei Kuroda, Yohei Kondo, Yasuhiro Kamei, Shigenori Nonaka, Saya Furukawa, Sakiya Yamamoto and Akira Satoh ()
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Ayaka Ohashi: 3-1-1 Tsushima-naka
Hirotaka Sakamoto: 3-1-1 Tsushima-naka
Junpei Kuroda: Suita
Yohei Kondo: Showa-ku
Yasuhiro Kamei: Myodaiji Nishigo-naka 38
Shigenori Nonaka: Myodaiji Nishigo-naka 38
Saya Furukawa: 3-1-1 Tsushima-naka
Sakiya Yamamoto: 3-1-1 Tsushima-naka
Akira Satoh: 3-1-1 Tsushima-naka

Nature Communications, 2025, vol. 16, issue 1, 1-18

Abstract: Abstract Type I collagen is a major component of the dermis and is formed by dermal fibroblasts. The development of dermal collagen structures has not been fully elucidated despite the major presence and importance of the dermis. This lack of understanding is due in part to the opacity of mammalian skin and it has been an obstacle to cosmetic and medical developments. We reveal the process of dermal collagen formation using the highly transparent skin of the axolotl and fluorescent collagen probes. We clarify that epidermal cells, not dermal fibroblasts, contribute to dermal collagen formation. Mesenchymal cells (fibroblasts) play a role in modifying the collagen fibers already built by keratinocytes. We confirm that collagen production by keratinocytes is a widely conserved mechanism in other model organisms. Our findings warrant a change in the current consensus about dermal collagen formation and could lead to innovations in cosmetology and skin medication.

Date: 2025
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DOI: 10.1038/s41467-025-57055-7

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