Metallaphotoredox-catalyzed alkynylcarboxylation of alkenes with CO2 and alkynes for expedient access to β-alkynyl acids

Jin-Cheng Xu, Jun-Ping Yue, Min Pan, Yi-Chi Chen, Wei Wang, Xi Zhou, Wei Zhang (), Jian-Heng Ye and Da-Gang Yu ()
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Jin-Cheng Xu: Sichuan University
Jun-Ping Yue: Sichuan University
Min Pan: Sichuan University
Yi-Chi Chen: Sichuan University
Wei Wang: Sichuan University
Xi Zhou: Sichuan University
Wei Zhang: Sichuan University
Jian-Heng Ye: Sichuan University
Da-Gang Yu: Sichuan University

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract Carboxylation with CO2 offers an attractive and sustainable access to valuable carboxylic acids. Among these methods, direct C−H carboxylation of terminal alkynes with CO2 has attracted much attention for one-carbon homologation of alkynes, enabling rapid synthesis of propiolic acids. In contrast, the multi-carbons homologation of alkynes with CO2 to construct important non-conjugated alkynyl-containing acids has not been reported. Herein, we present alkynylcarboxylation of alkenes with CO2 via photoredox and copper dual catalysis. This protocol provides a direct and practical method to form valuable non-conjugated alkynyl acids from readily available alkynes, alkenes and CO2. Additionally, this approach also features mild (room temperature, 1 atm of CO2) and redox-neutral conditions, high atom and step economy, good functional group tolerance, and high selectivities. Moreover, diverse transformations of the β-alkynyl acid products and the rapid synthesis of bioactive molecule (GPR40/FFA1 agonist) further illustrate the synthetic utility of this methodology.

Date: 2025
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DOI: 10.1038/s41467-025-57060-w

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