Structure of an F-type phage tail-like bacteriocin from Listeria monocytogenes

Zhiwei Gu, Xiaofei Ge () and Jiawei Wang ()
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Zhiwei Gu: Tsinghua University
Xiaofei Ge: City University of Macau
Jiawei Wang: Tsinghua University

Nature Communications, 2025, vol. 16, issue 1, 1-9

Abstract: Abstract F-type phage tail-like bacteriocins (PTLBs) are high-molecular-weight protein complexes exhibiting bactericidal activity and share evolutionary similarities with the tails of non-contractile siphoviruses. In this study, we present the atomic structure of monocin, a genetically engineered F-type PTLB from Listeria monocytogenes. Our detailed atomic-level analysis, excluding two chaperone proteins, provides crucial insights into the molecular architecture of F-type PTLBs. The core structure of monocin resembles TP901-1-like phage tails, featuring three side fibers with receptor-binding domains that connect to the baseplate for host adhesion. Based on these findings, we propose a potential mechanism by which F-type PTLBs induce cell death, offering a foundation for developing targeted antibacterial therapies.

Date: 2025
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DOI: 10.1038/s41467-025-57075-3

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