Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis

Samir Abu-Rumeileh, Leila Scholle, Alexander Mensch, Henning Großkopf, Antonia Ratti, Anna Kölsch, Gisela Stoltenburg-Didinger, Julian Conrad, Anna De Gobbi, Lorenzo Barba, Petra Steinacker, Hans-Wolfgang Klafki, Patrick Oeckl, Steffen Halbgebauer, Caroline Stapf, Andreas Posa, Thomas Kendzierski, Vincenzo Silani, Lucrezia Hausner, Nicola Ticozzi, Lutz Froelich, Jochen Hans Weishaupt, Federico Verde and Markus Otto ()
Additional contact information
Samir Abu-Rumeileh: Martin-Luther-University Halle-Wittenberg
Leila Scholle: Martin-Luther-University Halle-Wittenberg
Alexander Mensch: Martin-Luther-University Halle-Wittenberg
Henning Großkopf: Martin-Luther-University Halle-Wittenberg
Antonia Ratti: IRCCS Istituto Auxologico Italiano
Anna Kölsch: Martin-Luther-University Halle-Wittenberg
Gisela Stoltenburg-Didinger: Martin-Luther-University Halle-Wittenberg
Julian Conrad: University of Heidelberg
Anna De Gobbi: IRCCS Istituto Auxologico Italiano
Lorenzo Barba: Martin-Luther-University Halle-Wittenberg
Petra Steinacker: Martin-Luther-University Halle-Wittenberg
Hans-Wolfgang Klafki: Georg-August University
Patrick Oeckl: Ulm University Hospital
Steffen Halbgebauer: Ulm University Hospital
Caroline Stapf: Martin-Luther-University Halle-Wittenberg
Andreas Posa: Martin-Luther-University Halle-Wittenberg
Thomas Kendzierski: Martin-Luther-University Halle-Wittenberg
Vincenzo Silani: IRCCS Istituto Auxologico Italiano
Lucrezia Hausner: University of Heidelberg
Nicola Ticozzi: IRCCS Istituto Auxologico Italiano
Lutz Froelich: University of Heidelberg
Jochen Hans Weishaupt: University of Heidelberg
Federico Verde: IRCCS Istituto Auxologico Italiano
Markus Otto: Martin-Luther-University Halle-Wittenberg

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer’s disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multicentre cohort of ALS (n = 152), AD (n = 111) cases and disease controls (n = 99) recruited from four different centres. Further, we investigated the existence of both p-tau species using immunohistochemistry (IHC) and mass spectrometry (MS) in muscle biopsies of ALS cases (IHC: n = 13, MS: n = 5) and disease controls (IHC: n = 14, MS: n = 5) from one cohort. Serum p-tau 181 and p-tau 217 were higher in AD and ALS patients compared to disease controls. IHC and MS analyses revealed the presence of p-tau 181 and 217 in muscle biopsies from both ALS cases and disease controls, with ALS samples showing increased p-tau reactivity in atrophic muscle fibres. Blood p-tau species could potentially be used to diagnose both ALS and AD.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-57144-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57144-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-57144-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().