Glutathione triggers leaf-to-leaf, calcium-based plant defense signaling

Rui Li, Yongfang Yang, Hao Lou, Weicheng Wang, Ran Du, Haidong Chen, Xiaoxi Du, Shuai Hu, Guo-Liang Wang (), Jianbin Yan (), Xiaoyi Shan () and Daoxin Xie ()
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Rui Li: Tsinghua University
Yongfang Yang: Tsinghua University
Hao Lou: Tsinghua University
Weicheng Wang: Tsinghua University
Ran Du: Chinese Academy of Agricultural Sciences
Haidong Chen: Chinese Academy of Agricultural Sciences
Xiaoxi Du: Tsinghua University
Shuai Hu: Tsinghua University
Guo-Liang Wang: Ohio State University
Jianbin Yan: Chinese Academy of Agricultural Sciences
Xiaoyi Shan: Tsinghua University
Daoxin Xie: Tsinghua University

Nature Communications, 2025, vol. 16, issue 1, 1-11

Abstract: Abstract Animals rely on nervous systems to cope with environmental variability, whereas plants are characterized by lack of nervous system but still have evolved systemic communication systems through signaling molecules that trigger long-distance defense signaling events when encountered with environmental challenges. Here, our genetic screening of the previously constructed hairpin RNA-based Arabidopsis library identifies a glutathione (GSH)-deficient mutant that has high accumulation of glutamate (Glu), a previously defined wound signal essential for activating plant defense, but disharmoniously exhibits attenuation of defense signaling events. We further uncover GSH as a critical signaling molecule that relies on GLUTAMATE RECEPTOR-LIKE 3.3 (GLR3.3) to trigger long-distance calcium-based defense signaling events in plants. Our findings offer new insights into highly sophisticated systemic defense systems evolved by plants to defend against herbivory and pathogen invasion.

Date: 2025
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DOI: 10.1038/s41467-025-57239-1

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