Rational design of phytovirucide inhibiting nucleocapsid protein aggregation in tomato spotted wilt virus

Ningning Zan, Jiao Li, Jiahui Yao, Shang Wu, Jianzhuan Li, Feifei Chen, Baoan Song () and Runjiang Song ()
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Ningning Zan: Guizhou University
Jiao Li: Guizhou University
Jiahui Yao: Guizhou University
Shang Wu: Guizhou University
Jianzhuan Li: Guizhou University
Feifei Chen: Guizhou University
Baoan Song: Guizhou University
Runjiang Song: Guizhou University

Nature Communications, 2025, vol. 16, issue 1, 1-18

Abstract: Abstract Ineffectiveness of managing plant viruses by chemicals has posed serious challenges in crop production. Recently, phase separation has shown to play a key role in viral lifecycle. Using inhibitors that can disturb biomolecular condensates formed by phase separation for virus control has been reported in medical field. However, the applicability of this promising antiviral tactic for plant protection has not been explored. Here, we report an inhibitor, Z9, that targets the tomato spotted wilt virus (TSWV) N protein. Z9 is capable of interacting with the amino acids in the nucleic acid binding region of TSWV N, disrupting the assembly of N and RNA into phase-separated condensates, the reduction of which is detrimental to the stability of the N protein. This study provides a strategy for phase separation-based plant virus control.

Date: 2025
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DOI: 10.1038/s41467-025-57281-z

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