Epigenomic and proteomic analyses provide insights into early-life immune regulation and asthma development in infants

Yijun Li, Zhaozhong Zhu, Carlos A. Camargo, Janice A. Espinola, Kohei Hasegawa and Liming Liang ()
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Yijun Li: Harvard T.H. Chan School of Public Health
Zhaozhong Zhu: Harvard Medical School
Carlos A. Camargo: Harvard Medical School
Janice A. Espinola: Harvard Medical School
Kohei Hasegawa: Harvard Medical School
Liming Liang: Harvard T.H. Chan School of Public Health

Nature Communications, 2025, vol. 16, issue 1, 1-14

Abstract: Abstract Infants with severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) face increased risks of respiratory diseases in childhood. We conduct epigenome-wide association studies in a multi-ethnic cohort of these infants. We identify 61 differentially methylated regions in infant blood (

Date: 2025
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DOI: 10.1038/s41467-025-57288-6

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