Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90%

Bing Zhang, Wei Liu, Zhu Liu, Yuhou Pei, Di Li, Hongbin Yang, Chuntian Qiu, Yang Fan, Yinghua Xu, Jie Ding, Lei Yu, Bin Liu () and Chenliang Su ()
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Bing Zhang: Shenzhen University
Wei Liu: Shenzhen University
Zhu Liu: Zhejiang University
Yuhou Pei: Zhejiang University
Di Li: Zhejiang University
Hongbin Yang: City University of Hong Kong
Chuntian Qiu: Shenzhen University
Yang Fan: Shenzhen University
Yinghua Xu: Zhejiang University of Technology
Jie Ding: City University of Hong Kong
Lei Yu: Yangzhou University
Bin Liu: City University of Hong Kong
Chenliang Su: Shenzhen University

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract Developing cost-effective and environmentally friendly approaches to synthesize brominated chemicals, which are important intermediates for the synthesis of various useful molecules such as pharmaceuticals, surfactants, pesticides, and biologically active heterocyclic compounds, is of great significance. Herein, we present a highly efficient electrochemical bromine evolution reaction over vacancy rich Co3O4 using cheap NaBr as the bromine source for the synthesis of valuable brominated fine chemicals and pharmaceuticals under ambient conditions. The introduction of oxygen vacancy onto Co3O4 can greatly enhance the activity and selectivity of bromine evolution reaction by optimizing Br* intermediate adsorption and desorption, enabling bromination of a series of bioactive molecules and pharmaceuticals at high yields.

Date: 2025
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DOI: 10.1038/s41467-025-57329-0

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