Portable molecular diagnostic platform for rapid point-of-care detection of mpox and other diseases

Matthew L. Cavuto, Kenny Malpartida-Cardenas, Ivana Pennisi, Marcus J. Pond, Sohail Mirza, Nicolas Moser, Mark Comer, Isobel Stokes, Lucy Eke, Sian Lant, Katarzyna M. Szostak-Lipowicz, Luca Miglietta, Oliver W. Stringer, Katerina-Theresa Mantikas, Rebecca P. Sumner, Frances Bolt, Shiranee Sriskandan, Alison Holmes, Pantelis Georgiou, David O. Ulaeto, Carlos Maluquer de Motes and Jesus Rodriguez-Manzano ()
Additional contact information
Matthew L. Cavuto: Imperial College London
Kenny Malpartida-Cardenas: Imperial College London
Ivana Pennisi: Imperial College London
Marcus J. Pond: Imperial College Healthcare NHS Trust
Sohail Mirza: Imperial College London
Nicolas Moser: Imperial College London
Mark Comer: Imperial College London
Isobel Stokes: University of Surrey
Lucy Eke: University of Surrey
Sian Lant: University of Surrey
Katarzyna M. Szostak-Lipowicz: Imperial College London
Luca Miglietta: Imperial College London
Oliver W. Stringer: Imperial College London
Katerina-Theresa Mantikas: Imperial College London
Rebecca P. Sumner: University of Surrey
Frances Bolt: Imperial College London
Shiranee Sriskandan: Imperial College London
Alison Holmes: Imperial College London
Pantelis Georgiou: Imperial College London
David O. Ulaeto: Defence Science and Technology Laboratory
Carlos Maluquer de Motes: University of Surrey
Jesus Rodriguez-Manzano: Imperial College London

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract The World Health Organization’s designation of mpox as a public health emergency of international concern in August 2024 underscores the urgent need for effective diagnostic solutions to combat this escalating threat. The rapid global spread of clade II mpox, coupled with the sustained human-to-human transmission of the more virulent clade I mpox in the Democratic Republic of Congo, highlights a critical gap in point-of-care diagnostics for this emergent disease. In response, we developed Dragonfly, a portable molecular diagnostic platform for point-of-care use that integrates power-free nucleic acid extraction (

Date: 2025
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DOI: 10.1038/s41467-025-57647-3

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