Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood

A. G. Allegrini (), L. J. Hannigan, L. Frach, W. Barkhuizen, J. R. Baldwin, O. A. Andreassen, D. Bragantini, L. Hegemann, A. Havdahl and J-B. Pingault
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A. G. Allegrini: University College London
L. J. Hannigan: Lovisenberg Diaconal Hospital
L. Frach: University College London
W. Barkhuizen: University College London
J. R. Baldwin: University College London
O. A. Andreassen: Oslo University Hospital
D. Bragantini: Lovisenberg Diaconal Hospital
L. Hegemann: Lovisenberg Diaconal Hospital
A. Havdahl: Lovisenberg Diaconal Hospital
J-B. Pingault: University College London

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract Childhood emotional and behavioural difficulties tend to co-occur and often precede diagnosed neuropsychiatric conditions. Identifying shared and specific risk factors for early-life mental health difficulties is therefore essential for prevention strategies. Here, we examine how parental risk factors shape their offspring’s emotional and behavioural symptoms (e.g. feelings of anxiety, and restlessness) using data from 14,959 genotyped family trios from the Norwegian Mother, Father and Child Cohort Study (MoBa). We model maternal reports of emotional and behavioural symptoms, organizing them into general and specific domains. We then investigate the direct (genetically transmitted) and indirect (environmentally mediated) contributions of parental polygenic risk for neuropsychiatric-related traits and whether these are shared across symptoms. We observe evidence consistent with an environmental route to general symptomatology beyond genetic transmission, while also demonstrating domain-specific direct and indirect genetic contributions. These findings improve our understanding of early risk pathways that can be targeted in preventive interventions aiming to interrupt the intergenerational cycle of risk transmission.

Date: 2025
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DOI: 10.1038/s41467-025-57694-w

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