Bicomponent nano- and microfiber aerogels for effective management of junctional hemorrhage

S. M. Shatil Shahriar, Syed Muntazir Andrabi, Al-Murtadha Al-Gahmi, Zishuo Yan, Alec D. McCarthy, Chenlong Wang, Zakariya A. Yusuf, Navatha Shree Sharma, Milton E. Busquets, Mallory I. Nilles, Carlos Poblete Jara, Kai Yang, Mark A. Carlson () and Jingwei Xie ()
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S. M. Shatil Shahriar: University of Nebraska Medical Center
Syed Muntazir Andrabi: University of Nebraska Medical Center
Al-Murtadha Al-Gahmi: University of Nebraska Medical Center
Zishuo Yan: University of Nebraska Medical Center
Alec D. McCarthy: University of Nebraska Medical Center
Chenlong Wang: University of Nebraska Medical Center
Zakariya A. Yusuf: University of Nebraska Medical Center
Navatha Shree Sharma: University of Nebraska Medical Center
Milton E. Busquets: University of Nebraska Medical Center
Mallory I. Nilles: University of Nebraska Medical Center
Carlos Poblete Jara: University of Nebraska Medical Center
Kai Yang: University of Nebraska Medical Center
Mark A. Carlson: University of Nebraska Medical Center
Jingwei Xie: University of Nebraska Medical Center

Nature Communications, 2025, vol. 16, issue 1, 1-20

Abstract: Abstract Managing junctional hemorrhage is challenging due to ineffective existing techniques, with the groin being the most common site, accounting for approximately 19.2% of potentially survivable field deaths. Here, we report a bicomponent nano- and microfiber aerogel (NMA) for injection into deep, narrow junctional wounds to effectively halt bleeding. The aerogel comprises intertwined poly(lactic acid) nanofibers and poly(ε-caprolactone) microfibers, with mechanical properties tunable through crosslinking. Optimized aerogels demonstrate improved resilience, toughness, and elasticity, enabling rapid re-expansion upon blood contact. They demonstrate superior blood absorption and clotting efficacy compared to commercial products (i.e., QuikClot® Combat Gauze and XStat®). Most importantly, in a lethal swine junctional wound model (Yorkshire swine, both male and female, n = 5), aerogel treatment achieved immediate hemostasis, a 100% survival rate, no rebleeding, hemodynamic stability, and stable coagulation, hematologic, and arterial blood gas testing.

Date: 2025
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DOI: 10.1038/s41467-025-57836-0

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