Pd-catalyzed deuteration of aryl halides with deuterium oxide

Yu Chen, Ruyi Yuan, Tongtong Zheng, Qingting Guo, Yingming Yao () and Li Zhang ()
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Yu Chen: Soochow University
Ruyi Yuan: Soochow University
Tongtong Zheng: Soochow University
Qingting Guo: Soochow University
Yingming Yao: Soochow University
Li Zhang: Soochow University

Nature Communications, 2025, vol. 16, issue 1, 1-7

Abstract: Abstract Late-stage deuteration of aryl halides with deuterium oxide is a highly desirable but challenging transformation, primarily due to the difficulty of activating inert carbon-halogen bonds and the umpolung of deuterium oxide in the presence of various functional groups. To achieve this transformation, efforts have been made to develop photo-chemical, electro-chemical, or mechano-chemical strategies. However, these approaches often require specialized setups or activated substrates. Despite the well-known functional group tolerance of palladium catalysis, which makes it valuable in late-stage functionalization, a palladium-catalyzed deuteration of aryl halides with deuterium oxide has remained elusive. Herein, a deuteration reaction of aryl bromides, chlorides, and triflates with deuterium oxide has been developed, through palladium catalysis. Chemical equivalent amount of D2O is required for inert substrates like aryl chlorides. The reaction features high functional group tolerance, making it suitable for late-stage deuteration.

Date: 2025
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DOI: 10.1038/s41467-025-57855-x

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