Can a single brain cell be surprised?

Karl J. Friston ()
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Karl J. Friston: University College London

Nature Communications, 2025, vol. 16, issue 1, 1-2

Abstract: A recent study by Buonomano et al. reports two important contributions; namely, empirical evidence for prediction error-like responses in single cells, using ex vivo preparations and optogenetics. Second, it foregrounds the role of asymmetric coupling in generating itinerant dynamics required for temporal prediction in neuronal circuits.

Date: 2025
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DOI: 10.1038/s41467-025-57975-4

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