Electronic vascular conduit for in situ identification of hemadostenosis and thrombosis in small animals and nonhuman primates

Zhirong Liu, Chuyu Tang, Nannan Han, Zhuoheng Jiang, Xi Liang, Shaobo Wang, Quanhong Hu, Cheng Xiong, Shuncheng Yao, Zhuo Wang, Zhong Lin Wang (), Duohong Zou () and Linlin Li ()
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Zhirong Liu: Chinese Academy of Sciences
Chuyu Tang: Chinese Academy of Sciences
Nannan Han: Shanghai Jiao Tong University School of Medicine
Zhuoheng Jiang: Chinese Academy of Sciences
Xi Liang: Chinese Academy of Sciences
Shaobo Wang: Chinese Academy of Sciences
Quanhong Hu: Chinese Academy of Sciences
Cheng Xiong: Chinese Academy of Sciences
Shuncheng Yao: Chinese Academy of Sciences
Zhuo Wang: Chinese Academy of Sciences
Zhong Lin Wang: Chinese Academy of Sciences
Duohong Zou: Shanghai Jiao Tong University School of Medicine
Linlin Li: Chinese Academy of Sciences

Nature Communications, 2025, vol. 16, issue 1, 1-14

Abstract: Abstract Patients suffering from coronary artery disease (CAD) or peripheral arterial disease (PAD) can benefit from bypass graft surgery. For this surgery, arterial vascular grafts have become promising alternatives when autologous grafts are inaccessible but suffer from numerous postimplantation challenges, particularly delayed endothelialization, intimal hyperplasia, high risk of thrombogenicity and restenosis, and difficulty in timely detection of these subtle pathological changes. We present an electronic vascular conduit that integrates flexible electronics into bionic vascular grafts for in situ, real-time and long-term monitoring for hemadostenosis and thrombosis concurrent with postoperative vascular repair. Following bypass surgery, the integrated bioelectronic sensor based on the triboelectric effect enables monitoring of the blood flow in the vascular graft and identification of lesions in real time for up to three months. In male nonhuman primate cynomolgus monkeys, the electronic vascular conduit, with an integrated wireless signal transmission module, enables wireless and real-time hemodynamic monitoring and timely identification of thrombi. This electronic vascular conduit demonstrates potential as a treatment-monitoring platform, providing a sensitive and intuitive monitoring technique during the critical period after bypass surgery in patients with CAD and PAD.

Date: 2025
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DOI: 10.1038/s41467-025-58056-2

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