Iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C–H bonds with TON over 1000000

Zong-Rui Li, Kun Zhan, Yi-Jie Wang, Liang-Liang Wu, Guo-Lin Lu, Hao-Yang Wang, Xiao-Long Wan, Zhen-Jiang Xu (), Kam-Hung Low and Chi-Ming Che ()
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Zong-Rui Li: Shanghai Institute of Organic Chemistry
Kun Zhan: The University of Hong Kong
Yi-Jie Wang: Shanghai Institute of Organic Chemistry
Liang-Liang Wu: Beijing Normal University
Guo-Lin Lu: Shanghai Institute of Organic Chemistry
Hao-Yang Wang: Shanghai Institute of Organic Chemistry
Xiao-Long Wan: Shanghai Institute of Organic Chemistry
Zhen-Jiang Xu: Shanghai Institute of Organic Chemistry
Kam-Hung Low: The University of Hong Kong
Chi-Ming Che: Shanghai Institute of Organic Chemistry

Nature Communications, 2025, vol. 16, issue 1, 1-11

Abstract: Abstract Selective functionalization of ubiquitous C-H bonds in organic molecules provides a straightforward and efficient approach to construct complex molecules with fewer synthetic steps and high atom economy, thus promoting more sustainable and economical chemical synthesis. A formidable challenge in the field is to increase the turnover numbers (TONs) for catalytic C-H functionalization reactions reported in the literature (generally

Date: 2025
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DOI: 10.1038/s41467-025-58316-1

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