Scaling-up molecular logic to meso-systems via self-assembly

Ze-Qing Chen, Brian Daly, Chao-Yi Yao, Hannah S. N. Crory, Yikai Xu, Ziwei Ye, H. Q. Nimal Gunaratne, Ayumi Kimura, Seiichi Uchiyama, Steven E. J. Bell, Eric V. Anslyn and A. Prasanna Silva ()
Additional contact information
Ze-Qing Chen: Queen’s University
Brian Daly: Queen’s University
Chao-Yi Yao: Yuelu District
Hannah S. N. Crory: Queen’s University
Yikai Xu: Queen’s University
Ziwei Ye: Queen’s University
H. Q. Nimal Gunaratne: Queen’s University
Ayumi Kimura: The University of Tokyo
Seiichi Uchiyama: The University of Tokyo
Steven E. J. Bell: Queen’s University
Eric V. Anslyn: Queen’s University
A. Prasanna Silva: Queen’s University

Nature Communications, 2025, vol. 16, issue 1, 1-7

Abstract: Abstract Due to the small size and biocompatibility of molecules, molecular logic-based computation is a gateway to the informational basis of life processes. Logic-based computation operates widely with discrete molecules of up to nanometric sizes. The contribution of molecule-based bulk materials of milli/centimetric size to the field has begun in more recent years. However, artificial molecule-based meso-scale systems which intrinsically perform logic operations are very rare. Here, we show that self-assembled systems consisting of cyclophane octacarboxylates and a cationic surfactant can perform such functions, where a membrane itself behaves as a Reset-Set Flip-Flop which is integrated with 7 more logic elements. Now that molecular logic-based computation operates across a wide range of contiguous size-scales, the way opens for its general use in information processing aspects of biology and synthetic biology.

Date: 2025
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DOI: 10.1038/s41467-025-58379-0

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