Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits

Lauren E. Petty, Hung-Hsin Chen, Elizabeth G. Frankel, Wanying Zhu, Carolina G. Downie, Mariaelisa Graff, Phillip Lin, Priya Sharma, Xinruo Zhang, Alyssa C. Scartozzi, Rashedeh Roshani, Joshua M. Landman, Michael Boehnke, Donald W. Bowden, John C. Chambers, Anubha Mahajan, Mark I. McCarthy, Maggie C. Y. Ng, Xueling Sim, Cassandra N. Spracklen, Weihua Zhang, Michael Preuss, Erwin P. Bottinger, Girish N. Nadkarni, Ruth J. F. Loos, Yii- Der Ida Chen, Jingyi Tan, Eli Ipp, Pauline Genter, Leslie S. Emery, Tin Louie, Tamar Sofer, Adrienne M. Stilp, Kent D. Taylor, Anny H. Xiang, Thomas A. Buchanan, Kathryn Roll, Chuan Gao, Nicholette D. Palmer, Jill M. Norris, Lynne E. Wagenknecht, Darryl Nousome, Rohit Varma, Roberta McKean-Cowdin, Xiuqing Guo, Yang Hai, Willa Hsueh, Kevin Sandow, Esteban J. Parra, Miguel Cruz, Adan Valladares-Salgado, Niels Wacher-Rodarte, Jerome I. Rotter, Mark O. Goodarzi, Stephen S. Rich, Alain Bertoni, Leslie J. Raffel, Jerry L. Nadler, Fouad R. Kandeel, Ravindranath Duggirala, John Blangero, Donna M. Lehman, Ralph A. DeFronzo, Farook Thameem, Yujie Wang, Sheila Gahagan, Estela Blanco, Raquel Burrows, Alicia Huerta-Chagoya, Jose C. Florez, Teresa Tusie-Luna, Clicerio González-Villalpando, Lorena Orozco, Christopher A. Haiman, Craig L. Hanis, Rebecca Rohde, Eric A. Whitsel, Alexander P. Reiner, Charles Kooperberg, Yun Li, Qing Duan, Miryoung Lee, Paulina Correa-Burrows, Susan K. Fried, Kari E. North, Joseph B. McCormick, Susan P. Fisher-Hoch, Eric R. Gamazon, Andrew P. Morris, Josep M. Mercader, Heather M. Highland and Jennifer E. Below ()
Additional contact information
Lauren E. Petty: Vanderbilt University Medical Center
Hung-Hsin Chen: Vanderbilt University Medical Center
Elizabeth G. Frankel: Vanderbilt University Medical Center
Wanying Zhu: Vanderbilt University Medical Center
Carolina G. Downie: University of North Carolina at Chapel Hill
Mariaelisa Graff: University of North Carolina at Chapel Hill
Phillip Lin: Vanderbilt University Medical Center
Priya Sharma: University of North Carolina at Chapel Hill
Xinruo Zhang: University of North Carolina at Chapel Hill
Alyssa C. Scartozzi: Vanderbilt University Medical Center
Rashedeh Roshani: Vanderbilt University Medical Center
Joshua M. Landman: Vanderbilt University Medical Center
Michael Boehnke: University of Michigan
Donald W. Bowden: Wake Forest School of Medicine
John C. Chambers: Imperial College London
Anubha Mahajan: University of Oxford
Mark I. McCarthy: University of Oxford
Maggie C. Y. Ng: Vanderbilt University Medical Center
Xueling Sim: National University of Singapore and National University Health System
Cassandra N. Spracklen: University of North Carolina at Chapel Hill
Weihua Zhang: Imperial College London
Michael Preuss: Icahn School of Medicine at Mount Sinai
Erwin P. Bottinger: Icahn School of Medicine at Mount Sinai
Girish N. Nadkarni: Icahn School of Medicine at Mount Sinai
Ruth J. F. Loos: Icahn School of Medicine at Mount Sinai
Yii- Der Ida Chen: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Jingyi Tan: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Eli Ipp: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Pauline Genter: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Leslie S. Emery: University of Washington
Tin Louie: University of Washington
Tamar Sofer: Harvard University
Adrienne M. Stilp: University of Washington
Kent D. Taylor: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Anny H. Xiang: Kaiser Permanente of Southern California
Thomas A. Buchanan: Keck School of Medicine of USC
Kathryn Roll: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Chuan Gao: Winston-
Nicholette D. Palmer: Wake Forest School of Medicine
Jill M. Norris: University of Colorado Denver
Lynne E. Wagenknecht: Wake Forest School of Medicine
Darryl Nousome: Keck School of Medicine of the University of Southern California
Rohit Varma: CHA Hollywood Presbyterian Medical Center
Roberta McKean-Cowdin: Keck School of Medicine of the University of Southern California
Xiuqing Guo: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Yang Hai: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Willa Hsueh: Ohio State University Wexner Medical Center
Kevin Sandow: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Esteban J. Parra: University of Toronto at Mississauga
Miguel Cruz: IMSS
Adan Valladares-Salgado: IMSS
Niels Wacher-Rodarte: Centro Medico Nacional Siglo XXI, IMSS
Jerome I. Rotter: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Mark O. Goodarzi: Cedars-Sinai Medical Center
Stephen S. Rich: University of Virginia
Alain Bertoni: Wake Forest School of Medicine
Leslie J. Raffel: UCI Irvine School of Medicine
Jerry L. Nadler: New York Medical College
Fouad R. Kandeel: City of Hope
Ravindranath Duggirala: University of Texas Rio Grande Valley
John Blangero: University of Texas Rio Grande Valley
Donna M. Lehman: University of Texas Health Science Center at San Antonio
Ralph A. DeFronzo: University of Texas Health Science Center at San Antonio
Farook Thameem: Kuwait University
Yujie Wang: University of North Carolina at Chapel Hill
Sheila Gahagan: University of California at San Diego
Estela Blanco: Pontificia Universidad Católica de Chile
Raquel Burrows: University of Chile
Alicia Huerta-Chagoya: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Jose C. Florez: Harvard Medical School
Teresa Tusie-Luna: Universidad Nacional Autónoma de México/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Clicerio González-Villalpando: Instituto Nacional de Salud Pública
Lorena Orozco: Instituto Nacional de Medicina Genómica
Christopher A. Haiman: Keck School of Medicine of USC
Craig L. Hanis: The University of Texas Health Science Center at Houston
Rebecca Rohde: University of North Carolina at Chapel Hill
Eric A. Whitsel: University of North Carolina at Chapel Hill
Alexander P. Reiner: University of Washington
Charles Kooperberg: Fred Hutchinson Cancer Research Center
Yun Li: University of North Carolina at Chapel Hill
Qing Duan: University of North Carolina at Chapel Hill
Miryoung Lee: University of Texas Health Science Center at Houston, Brownsville Regional Campus
Paulina Correa-Burrows: University of Chile
Susan K. Fried: Icahn School of Medicine at Mount Sinai
Kari E. North: University of North Carolina at Chapel Hill
Joseph B. McCormick: University of Texas Health Science Center at Houston, Brownsville Regional Campus
Susan P. Fisher-Hoch: University of Texas Health Science Center at Houston, Brownsville Regional Campus
Eric R. Gamazon: Vanderbilt University Medical Center
Andrew P. Morris: University of Manchester
Josep M. Mercader: Harvard Medical School
Heather M. Highland: University of North Carolina at Chapel Hill
Jennifer E. Below: Vanderbilt University Medical Center

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.

Date: 2025
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-58574-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58574-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-58574-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().