The role of pyruvate dehydrogenase in the lifespan determination of daphnids

Wenkai Chen, Xueying Xu, Zhidan Zeng, Mingsen Zhou, Jiying Chen, Guangfu Hu, Anfu Shen, Dapeng Li and Liu Xiangjiang ()
Additional contact information
Wenkai Chen: Huazhong Agricultural University
Xueying Xu: Huazhong Agricultural University
Zhidan Zeng: Huazhong Agricultural University
Mingsen Zhou: Huazhong Agricultural University
Jiying Chen: Huazhong Agricultural University
Guangfu Hu: Huazhong Agricultural University
Anfu Shen: Huazhong Agricultural University
Dapeng Li: Huazhong Agricultural University
Liu Xiangjiang: Huazhong Agricultural University

Nature Communications, 2025, vol. 16, issue 1, 1-14

Abstract: Abstract The general association between longevity and energy metabolism has been well-documented for some time, yet the specific metabolic processes that regulate longevity remain largely unexplored. In contrast to the common active swimming daphnids (e.g., Daphnia sinensis), Simocephalus vetulus is notable for being sedentary and having a lower metabolic rate, yet it has a longer lifespan than D. sinensis. In this study, metabolomic analysis and drug validation experiments are employed to demonstrate that the lower pyruvate dehydrogenase (PDH) activity reduces the locomotor performance of S. vetulus and to identify PDH activity as a regulator of the lifespan of daphnids. Inhibition of PDH activity in daphnids by CPI-613 attenuates its ATP supply and locomotor performance but significantly induces longevity. The study also determines that the invertebrate neurotransmitter octopamine and temperature have a significant impact on PDH activity and modulate daphnids lifespan. And when the effects of temperature and octopamine on PDH activity are counteracted by inhibitors or agonists, the impact on lifespan becomes ineffective. These results support an important role for PDH in lifespan regulation and locomotor performance in daphnids and provide insights into the metabolic regulation of lifespan.

Date: 2025
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-58666-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58666-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-58666-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().