Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes

Alex Soupir, Oscar E. Ospina, Oliver Hampton, Michelle Churchman, Michael Radmacher, Dale Hedges, David McKean, Phaedra Agius, Saman Zeeshan, Nathan D. Seligson, Raphael Pollock, David Liebner, James L. Chen, Gabriel Tinoco, Bodour Salhia, Martin McCarter, Breelyn A. Wilky, Benjamin J. Miller, Michael J. Cavnar, John S. Groundland, Bryan P. Schneider, Gregory Riedlinger, Stephen B. Edge, Christopher A. Moskaluk, Kenneth Cardona, Abdul Rafeh Naqash, Ricardo J. Gonzalez, John E. Mullinax, David M. Joyce, Odion Binitie, G. Douglas Letson, Arash O. Naghavi, Mihaela Druta, Damon R. Reed, Erin M. Siegel, Jamie K. Teer, Brooke L. Fridley and Andrew S. Brohl ()
Additional contact information
Alex Soupir: Moffitt Cancer Center
Oscar E. Ospina: Moffitt Cancer Center
Oliver Hampton: Aster Insights
Michelle Churchman: Aster Insights
Michael Radmacher: Aster Insights
Dale Hedges: Aster Insights
David McKean: Aster Insights
Phaedra Agius: Aster Insights
Saman Zeeshan: University of Missouri
Nathan D. Seligson: University of Florida
Raphael Pollock: The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University Wexner Medical Center
David Liebner: The Ohio State University Wexner Medical Center
James L. Chen: The Ohio State University Wexner Medical Center
Gabriel Tinoco: The Ohio State University Wexner Medical Center
Bodour Salhia: Los Angeles
Martin McCarter: University of Colorado School of Medicine
Breelyn A. Wilky: University of Colorado School of Medicine
Benjamin J. Miller: University of Iowa
Michael J. Cavnar: University of Kentucky
John S. Groundland: Huntsman Cancer Institute
Bryan P. Schneider: Indiana University Simon Comprehensive Cancer Center
Gregory Riedlinger: Rutgers Cancer Institute of New Jersey
Stephen B. Edge: Roswell Park Comprehensive Cancer Center
Christopher A. Moskaluk: University of Virginia
Kenneth Cardona: Emory University
Abdul Rafeh Naqash: University of Oklahoma Health Sciences
Ricardo J. Gonzalez: Moffitt Cancer Center
John E. Mullinax: Moffitt Cancer Center
David M. Joyce: Moffitt Cancer Center
Odion Binitie: Moffitt Cancer Center
G. Douglas Letson: Moffitt Cancer Center
Arash O. Naghavi: Moffitt Cancer Center
Mihaela Druta: Moffitt Cancer Center
Damon R. Reed: Moffitt Cancer Center
Erin M. Siegel: Moffitt Cancer Center
Jamie K. Teer: Moffitt Cancer Center
Brooke L. Fridley: Moffitt Cancer Center
Andrew S. Brohl: Moffitt Cancer Center

Nature Communications, 2025, vol. 16, issue 1, 1-11

Abstract: Abstract Given their rarity and diversity, a fundamental understanding of the genomic underpinnings for many sarcoma subtypes is still lacking. To better define the molecular landscape of this group of diseases, we perform matched whole exome sequencing and RNA sequencing on a cohort of 1340 sarcoma tumor specimens. We identify recurrent somatic mutations and observe an increased mutational burden in metastatic vs. primary samples (p

Date: 2025
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DOI: 10.1038/s41467-025-58678-6

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