Low pressure amide hydrogenation enabled by magnetocatalysis

Sheng-Hsiang Lin, Sihana Ahmedi, Aaron Kretschmer, Carlotta Campalani, Yves Kayser, Liqun Kang, Serena DeBeer, Walter Leitner and Alexis Bordet ()
Additional contact information
Sheng-Hsiang Lin: Max Planck Institute for Chemical Energy Conversion
Sihana Ahmedi: Max Planck Institute for Chemical Energy Conversion
Aaron Kretschmer: Max Planck Institute for Chemical Energy Conversion
Carlotta Campalani: Max Planck Institute for Chemical Energy Conversion
Yves Kayser: Max Planck Institute for Chemical Energy Conversion
Liqun Kang: Max Planck Institute for Chemical Energy Conversion
Serena DeBeer: Max Planck Institute for Chemical Energy Conversion
Walter Leitner: Max Planck Institute for Chemical Energy Conversion
Alexis Bordet: Max Planck Institute for Chemical Energy Conversion

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract The catalytic hydrogenation of amides with molecular hydrogen (H2) is an appealing route for the synthesis of valuable amines entering in the preparation of countless organic compounds. Running effective amide hydrogenation under mild H2 pressures is challenging although desirable to preclude the need for specialized high-pressure technologies in research and industry. Here we show that magnetocatalysis with standard supported catalysts enables unprecedented amide hydrogenation at mild conditions. Widely available and commercial platinum on alumina (Pt/Al2O3) was functionalized with iron carbide nanoparticles (ICNPs) to allow for localized and rapid magnetic induction heating resulting in the activation of neighboring Pt sites by thermal energy transfer. Exposure of the ICNPs@Pt/Al2O3 catalyst to an alternating current magnetic field enables highly active and selective hydrogenation of a range of amides at a reactor temperature of 150 °C under 3 bar or even ambient pressure of H2. ICNPs@Pt/Al2O3 reacts adaptively to fluctuations in electricity supply mimicking the use of intermittent renewable energy sources. This work may pave the way toward a greatly enhanced practicability of amide hydrogenation at the laboratory and production scales, and demonstrates more generally the broad potential of the emerging field of magnetocatalysis for synthetic chemistry.

Date: 2025
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-58713-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58713-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-58713-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().