A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein

Yiming Chen, Dehui Kong, Zongkuan Wang, Jiaqian Liu, Linghan Wang, Keli Dai, Jialun Ji, Wei Chen, Xiong Tang, Mingxing Wen, Xu Zhang, Huajian Zhang, Chengzhi Jiao, Li Sun, Haiyan Wang, Xingru Fei, Hong Guo, Bingjian Sun, Xiaorong Tao, Wei Wang, Jian Yang, Xiue Wang () and Jin Xiao ()
Additional contact information
Yiming Chen: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Dehui Kong: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Zongkuan Wang: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Jiaqian Liu: Ningbo University
Linghan Wang: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Keli Dai: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Jialun Ji: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Wei Chen: Nanjing University
Xiong Tang: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Mingxing Wen: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Xu Zhang: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Huajian Zhang: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Chengzhi Jiao: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Li Sun: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Haiyan Wang: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Xingru Fei: Yandu District Agricultural Science Research Institute
Hong Guo: Yandu District Agricultural Science Research Institute
Bingjian Sun: Henan Agricultural University
Xiaorong Tao: Nanjing Agricultural University
Wei Wang: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Jian Yang: Ningbo University
Xiue Wang: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP
Jin Xiao: National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP

Nature Communications, 2025, vol. 16, issue 1, 1-16

Abstract: Abstract Ym1 is the most widely utilized gene for wheat yellow mosaic virus (WYMV) disease control in worldwide wheat breeding. Here, we successfully isolated the responsible gene for Ym1. It encodes a typical CC-NBS-LRR type R protein, which is specifically expressed in root and induced upon WYMV infection. Ym1-mediated WYMV resistance is likely achieved by blocking viral transmission from the root cortex into steles, thereby preventing systemic movement to aerial tissues. Ym1 CC domain is essential for triggering cell death. Ym1 specifically interacts with WYMV coat protein, and this interaction leads to nucleocytoplasmic redistribution, a process for transitioning Ym1 from an auto-inhibited to an activated state. The activation subsequently elicits hypersensitive responses and establishes WYMV resistance. Ym1 is likely introgressed from the sub-genome Xn or Xc of polyploid Aegilops species. The findings highlight an exogenous-introgressed and root-specifically expressed R gene that confers WYMV resistance by recognizing the viral component.

Date: 2025
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DOI: 10.1038/s41467-025-58816-0

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