Disease-specific B cell clones are shared between patients with Crohn’s disease

Prasanti Kotagiri (), William M. Rae, Laura Bergamaschi, Diana Pombal, Ji-Yeun Lee, Nurulamin M. Noor, Raoul S. Sojwal, Samuel J. S. Rubin, Lukas W. Unger, Sofie H. Tolmeijer, Giulia Manferrari, Rachael J. M. Bashford-Rogers, David B. Bingham, Anton Stift, Stephan Rogalla, John Gubatan, James C. Lee, Kenneth G. C. Smith, Eoin F. McKinney, Scott D. Boyd and Paul A. Lyons ()
Additional contact information
Prasanti Kotagiri: University of Cambridge
William M. Rae: University of Cambridge
Laura Bergamaschi: University of Cambridge
Diana Pombal: University of Cambridge School of Clinical Medicine
Ji-Yeun Lee: Stanford University
Nurulamin M. Noor: University of Cambridge School of Clinical Medicine
Raoul S. Sojwal: Stanford University
Samuel J. S. Rubin: Stanford University
Lukas W. Unger: University of Cambridge
Sofie H. Tolmeijer: University of Cambridge School of Clinical Medicine
Giulia Manferrari: University of Cambridge School of Clinical Medicine
Rachael J. M. Bashford-Rogers: University of Cambridge School of Clinical Medicine
David B. Bingham: Stanford University
Anton Stift: Medical University of Vienna
Stephan Rogalla: Stanford University
John Gubatan: Stanford University
James C. Lee: University of Cambridge
Kenneth G. C. Smith: University of Cambridge
Eoin F. McKinney: University of Cambridge
Scott D. Boyd: Stanford University
Paul A. Lyons: University of Cambridge

Nature Communications, 2025, vol. 16, issue 1, 1-13

Abstract: Abstract B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn’s disease (CD). How these B cell perturbations contribute to disease remains largely unknown. Here, we perform deep sequencing of the B cell receptor (BCR) repertoire in four cohorts of patients with CD, together with healthy controls and patients with UC. We identify BCR clones that are shared between patients with CD but not found in healthy individuals nor in patients with UC, indicating CD-associated B cell immune responses. Shared clones are present in the inflamed gut mucosa, draining intestinal lymph nodes and blood, suggesting the presence of common CD-associated antigens that drive B cell responses in CD patients.

Date: 2025
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DOI: 10.1038/s41467-025-58977-y

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